JAWS coordinates chondrogenesis and synovial joint positioning

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JAWS coordinates chondrogenesis and synovial joint positioning.

Properly positioned synovial joints are crucial to coordinated skeletal movement. Despite their importance for skeletal development and function, the molecular mechanisms that underlie joint positioning are not well understood. We show that mice carrying an insertional mutation in a previously uncharacterized gene, which we have named Jaws (joints abnormal with splitting), die perinatally with ...

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ژورنال

عنوان ژورنال: Development

سال: 2008

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.019950